Boston United made one change from the side which knocked Southport FC out of the FA Trophy last weekend.
Boston boss Dennis Greene reverted back to a 4-3-3 formation for the Skrill North clash at Nethermoor Park. Defender Stefan Galinski dropped to the bench to be replaced with Spencer Weir-Daley brought back into the attack.
Teenage goalkeeper Sam Vince was also replaced, with first choice Lewis King taking up the role in the goal. Vince had been brought in for the trip to Southport after King was cup tied.
Both sides headed into the match on the back of some strong form. Boston United had managed five games unbeaten, while Guiseley have managed a six game unbeaten run in the league which included four wins.
Boston United (4-3-3): King; Marrs, Garner, Piergianni, Steer; Marhsall, Ross (cpt), Hall; Miller, Newsham, Weir-Daley. Subs: Aujla, Milnes, Sansara, Sanders, Galinski.
Guiseley: (4-2-3-1): Drench; Holdsworth, Lockwood, Hall; Meynell; Rea, Boshell; Brooksby, Forrest, Rothery; Johnson. Subs: Lawlor, Potts, Hobson, Parker, Dickinson.