Jamie Yates says Gainsborough Trinity can upset the form book and tame the Lions on Saturday.
The Trinity wideman, who scored in Tuesday night's 1-1 draw at Stalybridge, says the Blues have got the squad and the team spirit to put a stop to Guiseley's free-scoring start to the season.
The West Yorkshire-based Lions have proved themselves king of the jungle so far, having scored 11 goals in just two games.
They are currently perched on top of the Blue Square Bet North table, but Yates insists previous results will mean nothing when the two teams meet at Nethermoor.
"We did not get off to the start we wanted against Gloucester last week, but we earned a very good draw on Tuesday night and we believe we have the game plan to get a result at Guiseley," said Yates.
"It was a very important point at Stalybridge and we will take a lot of confidence from that. We have to play everyone twice, so we may as well get the Guiseley trip out of the way early.
"It will be a tough test, but we will be aiming to battle and fight and stay in the game as long as possible and the longer it goes without a goal the better we will get.
"This league is very unpredictable. Yes, they (Guiseley) have been scoring goals, but we have some experienced players here now and we certainly have the spirit and togetherness you need when it gets tough."
In a difficult opening week, Trinity travelled to Stalybridge on Tuesday night following a 1-0 defeat at home against Gloucester on Saturday.
The Blues were trailing to a Joel Bembo-Leta goal before Yates equalised with a free-kick after 75 minutes to seal Trinity's first point of the campaign.
Trinity boss Steve Housham was delighted to head back to Lincolnshire with his side's first point of the season in the bag.
"It gets us up and running," Housham said.
"Against Guiseley, we might have to park the team bus in front of the goal, because they will be on a high.
"Already, we are travelling away to the league leaders and there's no doubt it will be tough. But, joking aside, we will never be defensive. If we want to achieve our aim this season, which is promotion, then we have to go to teams like Guisely and get a result.
"We will go there with that kind of attitude. We are a strong unit. I like to let the opposition worry about us, but when it comes to defending, we have the defenders to make things very difficult for Guiseley. We want to be the first team to beat them.
"We were so much better on Tuesday night and it will lift us. Stalybridge are a very good, young side and, at the end, we could have nicked a win."