A woman has been seriously injured in a crash involving a car and a lorry on the A46 near Osgodby, Market Rasen.
The incident, which involved a Renault flat-bed lorry and a grey Honda CRV estate, was reported at 8.15am.
Lincolnshire Fire & Rescue have been dealing with a coolant spill from the lorry.
The road was closed at the junction of the A46 and B1434 at 8.30am and is expected to re-open at about midday.
The driver of the Honda was taken to hospital in Grimsby with serious injuries.